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Association between HMGB1 and COPD: A Systematic Review
المؤلفون المشاركون
Navarra, Michele
Gangemi, Sebastiano
Casciaro, Marco
Trapani, Giovanni
Quartuccio, Sebastiano
Pioggia, Giovanni
Imbalzano, Egidio
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
HMGB1 is an alarmin, a protein that warns and activates inflammation.
Chronic obstructive pulmonary disease (COPD) is characterised by a progressive airflow obstruction and airway inflammation.
Current anti-inflammatory therapies are poorly effective in maintaining lung function and symptoms of COPD.
This underlines the need for finding new molecular targets involved in disease pathogenesis in order to block pathology progression.
This review aims to analyse latest advances on HMGB1 role, utilisation, and potential application in COPD.
To this purpose we reviewed experimental studies that investigated this alarmin as marker as well as a potential treatment in chronic obstructive pulmonary disease.
This systematic review was conducted according to PRISMA guidelines.
In almost all the studies, it emerged that HMGB1 levels are augmented in smokers and in patients affected by COPD.
It emerged that cigarette smoking, the most well-known causative factor of COPD, induces neutrophils death and necrosis.
The necrosis of neutrophil cells leads to HMGB1 release, which recruits other neutrophils in a self-maintaining process.
According to the results reported in the paper both inhibiting HMGB1 and its receptor (RAGE) and blocking neutrophils necrosis (inducted by cigarette smoking) could be the aim for further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gangemi, Sebastiano& Casciaro, Marco& Trapani, Giovanni& Quartuccio, Sebastiano& Navarra, Michele& Pioggia, Giovanni…[et al.]. 2015. Association between HMGB1 and COPD: A Systematic Review. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gangemi, Sebastiano…[et al.]. Association between HMGB1 and COPD: A Systematic Review. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gangemi, Sebastiano& Casciaro, Marco& Trapani, Giovanni& Quartuccio, Sebastiano& Navarra, Michele& Pioggia, Giovanni…[et al.]. Association between HMGB1 and COPD: A Systematic Review. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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