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Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection
المؤلفون المشاركون
Helmin-Basa, Anna
Bodnar, Magdalena
Marszalek, Andrzej
Grzywa, Renata
Czerwionka-Szaflarska, Mieczyslawa
Szaflarska-Poplawska, Anna
Mierzwa, Grazyna
Nowak, Magdalena
Dzierzanowska-Fangrat, Katarzyna
Michalkiewicz, Jacek
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the expression of innate immunity components and cytokines in the gastric mucosa among H.
pylori infected and uninfected children.
Materials and Methods.
Biopsies of the antral gastric mucosa from children with dyspeptic symptoms were evaluated.
Gene expressions of innate immunity receptors and cytokines were measured by quantitative real-time PCR.
The protein expression of selected molecules was tested by immunohistochemistry.
Results.
H.
pylori infection did not lead to a significant upregulation of MyD88, TLR2, TLR4, CD14, TREM1, and TREM2 mRNA expression but instead resulted in high mRNA expression of IL-6, IL-10, IFN-γ, TNF-α, and CD163.
H.
pylori cagA(+) infection was associated with higher IL-6 and IL-10 mRNA expression, as compared to cagA(−) strains.
H.
pylori infected children showed increased IFN-γ and TNF-α protein levels.
IFN-γ mRNA expression correlated with both H.
pylori density of colonization and lymphocytic infiltration in the gastric mucosa, whereas TNF-α protein expression correlated with bacterial density.
Conclusion.
H.
pylori infection in children was characterized by (a) Th1 expression profile, (b) lack of mRNA overexpression of natural immunity receptors, and (c) strong anti-inflammatory activities in the gastric mucosa, possibly resulting from increased activity of anti-inflammatory M2 macrophages.
This may explain the mildly inflammatory gastric inflammation often observed among H.
pylori infected children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Michalkiewicz, Jacek& Helmin-Basa, Anna& Grzywa, Renata& Czerwionka-Szaflarska, Mieczyslawa& Szaflarska-Poplawska, Anna& Mierzwa, Grazyna…[et al.]. 2015. Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072166
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Michalkiewicz, Jacek…[et al.]. Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072166
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Michalkiewicz, Jacek& Helmin-Basa, Anna& Grzywa, Renata& Czerwionka-Szaflarska, Mieczyslawa& Szaflarska-Poplawska, Anna& Mierzwa, Grazyna…[et al.]. Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072166
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072166
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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