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Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients
المؤلفون المشاركون
Hofer, Stefan
Zivkovic, Aleksandar R.
Schmidt, Karsten
Sigl, Annette
Decker, Sebastian O.
Brenner, Thorsten
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Systemic inflammation is an immune response to a nonspecific insult of either infectious or noninfectious origin and remains a challenge in the intensive care units with high mortality rate.
Cholinergic neurotransmission plays an important role in the regulation of the immune response during inflammation.
We hypothesized that the activity of butyrylcholinesterase (BChE) might serve as a marker to identify and prognose systemic inflammation.
By using a point-of-care-testing (POCT) approach we measured BChE activity in patients with severe systemic inflammation and healthy volunteers.
We observed a decreased BChE activity in patients with systemic inflammation, as compared to that of healthy individuals.
Furthermore, BChE activity showed an inverse correlation with the severity of the disease.
Although hepatic function has previously been found essential for BChE production, we show here that the reduced BChE activity associated with systemic inflammation occurs independently of and is thus not caused by any deficit in liver function in these patients.
A POCT approach, used to assess butyrylcholinesterase activity, might further improve the therapy of the critically ill patients by minimizing time delays between the clinical assessment and treatment of the inflammatory process.
Hence, assessing butyrylcholinesterase activity might help in early detection of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zivkovic, Aleksandar R.& Schmidt, Karsten& Sigl, Annette& Decker, Sebastian O.& Brenner, Thorsten& Hofer, Stefan. 2015. Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072224
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zivkovic, Aleksandar R.…[et al.]. Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072224
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zivkovic, Aleksandar R.& Schmidt, Karsten& Sigl, Annette& Decker, Sebastian O.& Brenner, Thorsten& Hofer, Stefan. Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072224
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072224
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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