Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort
المؤلفون المشاركون
Spinelli, F. R.
Valesini, Guido
Conti, Fabrizio
Ceccarelli, Fulvia
Massaro, Laura
Truglia, Simona
Miranda, Francesca
Elisa, Marocchi
Alessandri, Cristiano
Perricone, Carlo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
The anti-dsDNA antibodies are a marker for Systemic Lupus Erythematosus (SLE) and 70–98% of patients test positive.
We evaluated the demographic, clinical, laboratory, and therapeutical features of a monocentric SLE cohort according to the anti-dsDNA status.
Methods.
We identified three groups: anti-dsDNA + (persistent positivity); anti-dsDNA ± (initial positivity and subsequent negativity during disease course); anti-dsDNA − (persistent negativity).
Disease activity was assessed by the European Consensus Lupus Activity Measurement (ECLAM).
Results.
We evaluated 393 patients (anti-dsDNA +: 62.3%; anti-dsDNA ±: 13.3%; anti-dsDNA −: 24.4%).
The renal involvement was significantly more frequent in anti-dsDNA + (30.2%), compared with anti-dsDNA ± and anti-dsDNA − (21.1% and 18.7%, resp.; P = 0.001 ).
Serositis resulted significantly more frequent in anti-dsDNA − (82.3%) compared to anti-dsDNA + and anti-dsDNA ± (20.8% and 13.4%, resp.; P < 0.0001 ).
The reduction of C4 serum levels was identified significantly more frequently in anti-dsDNA + and anti-dsDNA ± (40.0% and 44.2%, resp.) compared with anti-dsDNA − (21.8%, P = 0.005 ).
We did not identify significant differences in the mean ECLAM values before and after modification of anti-dsDNA status ( P = 0.7 ).
Conclusion.
Anti-dsDNA status influences the clinical and immunological features of SLE patients.
Nonetheless, it does not appear to affect disease activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conti, Fabrizio& Ceccarelli, Fulvia& Perricone, Carlo& Massaro, Laura& Elisa, Marocchi& Miranda, Francesca…[et al.]. 2015. Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conti, Fabrizio…[et al.]. Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conti, Fabrizio& Ceccarelli, Fulvia& Perricone, Carlo& Massaro, Laura& Elisa, Marocchi& Miranda, Francesca…[et al.]. Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر