Cancer Cachexia and MicroRNAs

المؤلفون المشاركون

Camargo, Rodolfo Gonzalez
Quintas Teixeira Ribeiro, Henrique
Geraldo, Murilo Vieira
Matos-Neto, Emídio
Neves, Rodrigo Xavier
Carlos Carnevali, Luiz
Donatto, Felipe Fedrizzi
Alcântara, Paulo S. M.
Ottoch, José P.
Seelaender, Marília

المصدر

Mediators of Inflammation

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-10-04

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض

الملخص EN

Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation.

The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor.

Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance.

Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood.

Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant.

MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation.

Different miRNA expression profiles are associated with different diseases and inflammatory processes.

miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation.

Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia.

Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Camargo, Rodolfo Gonzalez& Quintas Teixeira Ribeiro, Henrique& Geraldo, Murilo Vieira& Matos-Neto, Emídio& Neves, Rodrigo Xavier& Carlos Carnevali, Luiz…[et al.]. 2015. Cancer Cachexia and MicroRNAs. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072274

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Camargo, Rodolfo Gonzalez…[et al.]. Cancer Cachexia and MicroRNAs. Mediators of Inflammation No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1072274

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Camargo, Rodolfo Gonzalez& Quintas Teixeira Ribeiro, Henrique& Geraldo, Murilo Vieira& Matos-Neto, Emídio& Neves, Rodrigo Xavier& Carlos Carnevali, Luiz…[et al.]. Cancer Cachexia and MicroRNAs. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072274

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1072274