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Pegylated Interferon-α Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat
المؤلفون المشاركون
Ashshi, Ahmed Mohamed
Mahamid, Elaf Wael
Al-Qadi, Noha Mohammed
Refaat, Bassem
El-Shemi, Adel Galal
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aims.
To measure the expression of activin βA-subunit, activin IIA and IIB receptors, Smad4, Smad7, and follistatin in the liver and the liver and serum concentrations of mature activin-A and follistatin in normal rat following treatment with pegylated interferon-α (Peg-INF-α) and ribavirin (RBV).
Materials and Methods.
40 male Wistar rats were divided equally into 4 groups: “control,” “Peg-only” receiving 4 injections of Peg-INF-α (6 µg/rat/week), “RBV-only” receiving ribavirin (4 mg/rat/day) orally, and “Peg & RBV” group receiving both drugs.
The expression of candidate molecules in liver was measured by immunohistochemistry and quantitative PCR.
The concentrations of mature proteins in serum and liver homogenate samples were measured using ELISA.
Results.
Peg-INF-α ± RBV altered the expression of all candidate molecules in the liver at the gene and protein levels P<0.05 and decreased activin-A and increased follistatin in serum and liver homogenates compared with the other groups P<0.05.
There were also significant correlations between serum and liver activin-A and follistatin.
Conclusion.
Peg-INF-α modulates the hepatic production of activin-A and follistatin, which can be detected in serum.
Further studies are needed to explore the role of Peg-INF-α on the production of activins and follistatin by the liver and immune cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Refaat, Bassem& El-Shemi, Adel Galal& Ashshi, Ahmed Mohamed& Mahamid, Elaf Wael& Al-Qadi, Noha Mohammed. 2015. Pegylated Interferon-α Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Refaat, Bassem…[et al.]. Pegylated Interferon-α Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat. Mediators of Inflammation No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1072314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Refaat, Bassem& El-Shemi, Adel Galal& Ashshi, Ahmed Mohamed& Mahamid, Elaf Wael& Al-Qadi, Noha Mohammed. Pegylated Interferon-α Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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