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PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy
المؤلفون المشاركون
Zhang, Chenbo
Li, Ajian
Li, Huaguang
Peng, Kangsheng
Wei, Qing
Lin, Moubin
Liu, Zhanju
Yin, Lu
Li, Jianwen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the correlation between PPP1R12A gene copy number and clinical outcomes of oxaliplatin-based regimen in stage III colorectal cancer (CRC).
Methods.
A total of 139 paraffin-embedded tissue samples of stage III CRC patients who received oxaliplatin-based treatment after radical surgery were recruited.
Genomic DNA was extracted and purified from paraffin-embedded sections.
Quantitative PCR methods were used to detect the relative copy number (RCN) of PPP1R12A.
Results.
Statistical analysis demonstrated that low PPP1R12A RCN was associated with poor RFS (HR=2.186, 95% CI: 1.293–3.696; P=0.003) and OS (HR=2.782, 95% CI: 1.531–5.052; P<0.001).
Additionally, when patients were stratified according to subgroups of stage III and tumor location, poor RFS and OS were also observed in the low PPP1R12A RCN group with significance (RFS: IIIB HR=2.870, P<0.001; colon HR=1.910, P=0.037; OS: IIIB HR=3.527, P<0.001; IIIC HR=2.662, P=0.049; rectum HR=4.229, P=0.002).
Conclusion.
Our findings suggest the copy number of PPP1R12A can independently predict recurrence and overall survival of stage III colorectal cancer patients receiving oxaliplatin-based chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Chenbo& Li, Ajian& Li, Huaguang& Peng, Kangsheng& Wei, Qing& Lin, Moubin…[et al.]. 2015. PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Chenbo…[et al.]. PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Chenbo& Li, Ajian& Li, Huaguang& Peng, Kangsheng& Wei, Qing& Lin, Moubin…[et al.]. PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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