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Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection
المؤلفون المشاركون
Langenmair, Elia Raoul
Kubosch, Eva J.
Beck, Samuel
Salzmann, Gian M.
Schmal, Hagen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Osteoarthritis is a long-term complication of acute articular infections.
However, the roles of cartilage and synovia in this process are not yet fully understood.
Methods.
Patients with acute joint infections were enrolled in a prospective clinical trial and the cytokine composition of effusions compared in patients with arthroplasty (n = 8) or with intact joints (n = 67).
Cytokines and cell function were also analyzed using a human in vitro model of joint infection.
Results.
Synovial IL-1β levels were significantly higher in patients with arthroplasty (p = 0.004).
Higher IL-1β concentrations were also found in the in vitro model without chondrocytes (p < 0.05).
The anti-inflammatory cytokines IL-4 and IL-10 were consistently expressed in vivo and in vitro, showing no association with the presence of cartilage or chondrocytes.
In contrast, FasL levels increased steadily in vitro, reaching higher levels without chondrocytes (p < 0.05).
Likewise, the viability of synovial fibroblasts (SFB) during infection was higher in the presence of chondrocytes.
The cartilage-metabolism markers aggrecan and bFGF were at higher concentrations in intact joints, but also synthesized by SFB.
Conclusions.
Our data suggest an anti-inflammatory effect of cartilage associated with the SFBs’ increased resistance to infections, which displayed the ability to effectively synthesize cartilage metabolites.The trial is registered with DRKS 00003536, MISSinG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Langenmair, Elia Raoul& Kubosch, Eva J.& Salzmann, Gian M.& Beck, Samuel& Schmal, Hagen. 2015. Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Langenmair, Elia Raoul…[et al.]. Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Langenmair, Elia Raoul& Kubosch, Eva J.& Salzmann, Gian M.& Beck, Samuel& Schmal, Hagen. Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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