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Decrease in Circulating Dendritic Cell Precursors in Patients with Peripheral Artery Disease
المؤلفون المشاركون
Figulla, Hans Reiner
Rohm, Ilonka
Atiskova, Yevgeniya
Kretzschmar, Daniel
Pistulli, Rudin
Yilmaz, Atilla
Schäller, Sebastian
Betge, Stefan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Peripheral artery disease (PAD) is a common manifestation of atherosclerosis.
Inflammation is important for initiation and progression of the disease.
Dendritic cells (DCs) as antigen-presenting cells play an important role in the immune system.
Therefore, we hypothesize that, in patients with PAD, DCPs might be reduced in blood due to their recruitment into the vascular wall and induce a proinflammatory response.
The numbers of myeloid DCPs, plasmacytoid DCPs, and total DCPs were analyzed by flow cytometry in blood of patients with PAD (n=52) compared to controls (n=60).
Femoralis plaques (n=12) of patients who underwent surgery were immunostained for CD209 and CD83 (mDCs) as well as CD304, CD123 (pDCs), and HLA-DR.
In patients with PAD, a significant decrease in mDCPs, pDCPs, and tDCPs was observed.
In immunostaining, markers indicative for mDCs (CD209: 16 versus 8 cells/0.1 mm2, P=0.02; CD83: 19 versus 5 cells/0.1 mm2, P=0.03) were significantly elevated in femoralis plaques compared to control vessels.
We show for the first time that mDCPs, pDCPs, and tDCPs are significantly reduced in patients with PAD.
Immunohistochemical analysis unraveled that the decrease in DCPs might be due to their recruitment into atherosclerotic plaques.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kretzschmar, Daniel& Rohm, Ilonka& Schäller, Sebastian& Betge, Stefan& Pistulli, Rudin& Atiskova, Yevgeniya…[et al.]. 2015. Decrease in Circulating Dendritic Cell Precursors in Patients with Peripheral Artery Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kretzschmar, Daniel…[et al.]. Decrease in Circulating Dendritic Cell Precursors in Patients with Peripheral Artery Disease. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kretzschmar, Daniel& Rohm, Ilonka& Schäller, Sebastian& Betge, Stefan& Pistulli, Rudin& Atiskova, Yevgeniya…[et al.]. Decrease in Circulating Dendritic Cell Precursors in Patients with Peripheral Artery Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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