Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals
المؤلفون المشاركون
Zhu, Ruirui
Liu, Cheng
Tang, Hongxia
Wang, Xiang
Zhu, Zhengfeng
Liu, Yuzhou
Mao, Xiaobo
Zhong, Yucheng
Zeng, Qiu-tang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Recently, several studies suggest that galectin-9 (Gal-9) might play a pivotal role in the pathogenesis of autoimmune diseases.
However, the exact role of Gal-9 in atherosclerosis remains to be elucidated.
Methods.
Serum Gal-9, high-sensitivity C-reactive protein (hs-CRP), interferon- (IFN-) γ, interleukin- (IL-) 4, IL-17, and transforming growth factor- (TGF-) β1 were measured.
The effect of Gal-9 on peripheral blood mononuclear cells (PBMC) was investigated in patients with normal coronary artery (NCA).
Results.
The lowest level of Gal-9 was found in the ST-segment elevation myocardial infarction (STEMI) group, followed by the non-ST-segment elevation ACS (NSTEACS), the NCA, and the stable angina pectoris (SAP) groups, respectively.
Additionally, Gal-9 was found to be independently associated with hs-CRP, lipoprotein(a), and creatinine.
Notably, Gal-9 was also noted to be an independent predictor of the Gensini score.
Moreover, Gal-9 suppressed T-helper 17 (Th17) and expanded regulatory T cells (Tregs), resulting in decreased IL-17 production and increased secretion of TGF-β1.
Conclusions.
Serum Gal-9 is associated with not only coronary artery disease (CAD), but also the severity of coronary arteries stenosis.
Gal-9 can expand Tregs and suppress Th17 development in activated PBMC, implying that Gal-9 has the potential to dampen the development of atherosclerosis and may be a new therapy for CAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Ruirui& Liu, Cheng& Tang, Hongxia& Zeng, Qiu-tang& Wang, Xiang& Zhu, Zhengfeng…[et al.]. 2015. Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Ruirui…[et al.]. Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Ruirui& Liu, Cheng& Tang, Hongxia& Zeng, Qiu-tang& Wang, Xiang& Zhu, Zhengfeng…[et al.]. Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر