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Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans
المؤلفون المشاركون
Velázquez-Moctezuma, Javier
Arana-Lechuga, Yoaly
Esqueda-León, Enrique
Terán-Pérez, Guadalupe
Gonzalez-Chavez, Antonio
Escobedo, Galileo
Leon-Cabrera, Sonia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects.
However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance.
Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI).
Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10).
Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA.
Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance.
Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample.
It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leon-Cabrera, Sonia& Arana-Lechuga, Yoaly& Esqueda-León, Enrique& Terán-Pérez, Guadalupe& Gonzalez-Chavez, Antonio& Escobedo, Galileo…[et al.]. 2015. Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leon-Cabrera, Sonia…[et al.]. Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leon-Cabrera, Sonia& Arana-Lechuga, Yoaly& Esqueda-León, Enrique& Terán-Pérez, Guadalupe& Gonzalez-Chavez, Antonio& Escobedo, Galileo…[et al.]. Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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