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5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response
المؤلفون المشاركون
Qiu, Yongming
Miao, Yi-Feng
Wu, Hui
Yang, Shao-Feng
Dai, Jiong
Tao, Zhen-Yi
Zhang, Xiao-Hua
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hypothermia treatment is a promising therapeutic strategy for brain injury.
We previously demonstrated that 5′-adenosine monophosphate (5′-AMP), a ribonucleic acid nucleotide, produces reversible deep hypothermia in rats when the ambient temperature is appropriately controlled.
Thus, we hypothesized that 5′-AMP-induced hypothermia (AIH) may attenuate brain ischemia/reperfusion injury.
Transient cerebral ischemia was induced by using the middle cerebral artery occlusion (MCAO) model in rats.
Rats that underwent AIH treatment exhibited a significant reduction in neutrophil elastase infiltration into neuronal cells and matrix metalloproteinase 9 (MMP-9), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR), and Toll-like receptor (TLR) protein expression in the infarcted area compared to euthermic controls.
AIH treatment also decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling- (TUNEL-) positive neuronal cells.
The overall infarct volume was significantly smaller in AIH-treated rats, and neurological function was improved.
By contrast, rats with ischemic brain injury that were administered 5′-AMP without inducing hypothermia had ischemia/reperfusion injuries similar to those in euthermic controls.
Thus, the neuroprotective effects of AIH were primarily related to hypothermia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 2015. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Yi-Feng…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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