5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response
المؤلفون المشاركون
Qiu, Yongming
Miao, Yi-Feng
Wu, Hui
Yang, Shao-Feng
Dai, Jiong
Tao, Zhen-Yi
Zhang, Xiao-Hua
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hypothermia treatment is a promising therapeutic strategy for brain injury.
We previously demonstrated that 5′-adenosine monophosphate (5′-AMP), a ribonucleic acid nucleotide, produces reversible deep hypothermia in rats when the ambient temperature is appropriately controlled.
Thus, we hypothesized that 5′-AMP-induced hypothermia (AIH) may attenuate brain ischemia/reperfusion injury.
Transient cerebral ischemia was induced by using the middle cerebral artery occlusion (MCAO) model in rats.
Rats that underwent AIH treatment exhibited a significant reduction in neutrophil elastase infiltration into neuronal cells and matrix metalloproteinase 9 (MMP-9), interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR), and Toll-like receptor (TLR) protein expression in the infarcted area compared to euthermic controls.
AIH treatment also decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling- (TUNEL-) positive neuronal cells.
The overall infarct volume was significantly smaller in AIH-treated rats, and neurological function was improved.
By contrast, rats with ischemic brain injury that were administered 5′-AMP without inducing hypothermia had ischemia/reperfusion injuries similar to those in euthermic controls.
Thus, the neuroprotective effects of AIH were primarily related to hypothermia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 2015. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Yi-Feng…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Yi-Feng& Wu, Hui& Yang, Shao-Feng& Dai, Jiong& Qiu, Yongming& Tao, Zhen-Yi…[et al.]. 5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain IschemiaReperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر