Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults

المؤلفون المشاركون

Daskalakis, Constantine
Cheng, Cynthia

المصدر

Mediators of Inflammation

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-10-13

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Proinflammatory adipokines (inflammation markers) from visceral adipose tissue may initiate the development of insulin resistance (IR) and endothelial dysfunction (ED).

This study’s objective was to investigate the association of five inflammation markers (CRP and four adipokines: IL-6, TNFα, PAI-1, and adiponectin) with IR (quantitative insulin resistance check index (QUICKI)), microvascular measures (capillary density and albumin-to-creatinine ratio (ACR)), and endothelial measures (forearm blood flow (FBF) increases from resting baseline to maximal vasodilation).

Analyses were conducted via multiple linear regression.

The 295 study participants were between 18 and 45 years of age, without diabetes or hypertension.

They included 24% African Americans and 21% Asians with average body mass index of 25.4 kg/m2.

All five inflammation markers were significantly associated with QUICKI.

All but adiponectin were significantly associated with capillary density, but none were associated with ACR.

Finally, IL-6 and PAI-1 were significantly associated with FBF increase.

We also identified a potential interaction between obesity and IL-6 among normal-weight and overweight participants: IL-6 appeared to be positively associated with QUICKI and capillary density (beneficial effect), but the inverse was true among obese individuals.

These study findings suggest that inflammation measures may be potential early markers of cardiovascular risk in young asymptomatic individuals.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cheng, Cynthia& Daskalakis, Constantine. 2015. Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072439

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cheng, Cynthia& Daskalakis, Constantine. Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072439

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cheng, Cynthia& Daskalakis, Constantine. Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072439

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1072439