Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy
المؤلفون المشاركون
Mainz, Jochen G.
Hentschel, Julia
Müller, Ulrike
Janhsen, Wibke K.
Hünniger, Kerstin
Hipler, Uta-Christina
Sonnemann, Jürgen
Pfister, Wolfgang
Böer, Klas
Lehmann, Thomas
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa.
The consecutive hosts’ release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction.
Objectives were to assess dynamics of protease : antiprotease ratios and pathogens in CF-UAW and LAW sampled by nasal lavage (NL) and sputum before and after intravenous- (IV-) antibiotic therapy.
Methods.
From 19 IV-antibiotic courses of 17 CF patients NL (10 mL/nostril) and sputum were collected before and after treatment.
Microbiological colonization and concentrations of NE/SLPI/CTSS (ELISA) and MMP-9/TIMP-1 (multiplex bead array) were determined.
Additionally, changes of sinonasal symptoms were assessed (SNOT-20).
Results.
IV-antibiotic treatment had more pronounced effects on inflammatory markers in LAW, whereas trends to decrease were also found in UAW.
Ratios of MMP-9/TIMP-1 were higher in sputum, and ratios of NE/SLPI were higher in NL.
Remarkably, NE/SLPI ratio was 10-fold higher in NL compared to healthy controls.
SNOT-20 scores decreased significantly during therapy ( P = 0.001 ) .
Conclusion.
For the first time, changes in microbiological patterns in UAW and LAW after IV-antibiotic treatments were assessed, together with changes of protease/antiprotease imbalances.
Delayed responses of proteases and antiproteases to IV-antibiotic therapy were found in UAW compared to LAW.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Müller, Ulrike& Hentschel, Julia& Janhsen, Wibke K.& Hünniger, Kerstin& Hipler, Uta-Christina& Sonnemann, Jürgen…[et al.]. 2015. Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Müller, Ulrike…[et al.]. Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Müller, Ulrike& Hentschel, Julia& Janhsen, Wibke K.& Hünniger, Kerstin& Hipler, Uta-Christina& Sonnemann, Jürgen…[et al.]. Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر