Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes
المؤلفون المشاركون
Holt, Charlotte Berg
Axelgaard, Esben
Nielsen, Gitte Krogh
Thiel, Steffen
Endo, Yuichi
Hansen, Troels Krarup
Østergaard, Jakob Appel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The innate immune system may have adverse effects in diabetes and cardiovascular disease.
The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes.
Recently mannan-binding lectin (MBL) was shown to worsen diabetic kidney changes.
We hypothesize that mouse ficolin B exerts detrimental effects in the diabetic kidney as seen for MBL.
Methods.
We induced diabetes with streptozotocin in female wild-type mice and ficolin B knockout mice and included two similar nondiabetic groups.
Renal hypertrophy and excretion of urinary albumin and creatinine were quantified to assess diabetic kidney damage.
Results.
In the wild-type groups, the kidney weighed 24% more in the diabetic mice compared to the controls.
The diabetes-induced increase in kidney weight was 29% in the ficolin B knockout mice, that is, equal to wild-type animals (two-way ANOVA, P=0.60).
In the wild-type mice the albumin-to-creatinine ratio (ACR) was 32.5 mg/g higher in the diabetic mice compared to the controls.
The difference was 62.5 mg/g in the ficolin B knockout mice, but this was not significantly different from the wild-type animals (two-way ANOVA, P=0.21).
Conclusions.
In conclusion, the diabetes-induced effects on kidney weight and ACR were not modified by the presence or absence of ficolin B.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holt, Charlotte Berg& Østergaard, Jakob Appel& Axelgaard, Esben& Nielsen, Gitte Krogh& Endo, Yuichi& Thiel, Steffen…[et al.]. 2015. Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072490
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holt, Charlotte Berg…[et al.]. Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072490
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holt, Charlotte Berg& Østergaard, Jakob Appel& Axelgaard, Esben& Nielsen, Gitte Krogh& Endo, Yuichi& Thiel, Steffen…[et al.]. Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072490
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072490
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر