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Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome
المؤلفون المشاركون
Parolini, Marina
Parodi, Oberdan
Cozzi, Lorena
Rocchiccioli, Silvia
Cecchettini, Antonella
Citti, Lorenzo
Parodi, Guido
Marcucci, Rossella
Romagnuolo, Ilaria
Giusti, Betti
Abbate, Rosanna
Gori, Anna Maria
Caruso, Raffaele
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
In acute coronary syndrome (ACS), inflammation and redox response are associated with increased residual platelet reactivity (RPR) on clopidogrel therapy.
We investigated whether clopidogrel interaction affects platelet function and modulates factors related to inflammation and oxidation in ACS patients differently responding to clopidogrel.
Material and Methods.
Platelet aggregation was measured in 29 ACS patients on dual (aspirin/clopidogrel) antiplatelet therapy.
Nonresponders (NR) were defined as RPR ≥70% by ADP.
Several inflammatory and redox parameters were assayed and platelet proteome was determined.
Results.
Eight (28%) out of 29 ACS patients resulted NR to clopidogrel.
At 24 hours, the levels of Th2-type cytokines IL-4, IFNγ, and MCP-1 were higher in NR, while blood GSH (r-GSHbl) levels were lower in NR than responders (R).
Proteomic analysis evidenced an upregulated level of platelet adhesion molecule, CD226, and a downregulation of the antioxidant peroxiredoxin-4.
In R patients the proinflammatory cytokine IL-6 decreased, while the anti-inflammatory cytokine IL-1Ra increased.
Conclusions.
In patients with high RPR on clopidogrel therapy, an unbalance of inflammatory factors, platelet adhesion molecules, and circulatory and platelet antioxidant molecules was observed during the acute phase.
Proinflammatory milieu persists in nonresponders for a long time after the acute event while antioxidant blood factors tend to conform to normal responsiveness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caruso, Raffaele& Rocchiccioli, Silvia& Gori, Anna Maria& Cecchettini, Antonella& Giusti, Betti& Parodi, Guido…[et al.]. 2015. Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caruso, Raffaele…[et al.]. Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caruso, Raffaele& Rocchiccioli, Silvia& Gori, Anna Maria& Cecchettini, Antonella& Giusti, Betti& Parodi, Guido…[et al.]. Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients during Acute Coronary Syndrome. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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