Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases
المؤلفون المشاركون
Waszczykowska, Elzbieta
Wozniacka, Anna
Wieczfinska, Joanna
Zebrowski, Michal
Eusebio, Makandjou-Ola
Pietruczuk, Miroslawa
Marian, Danilewicz
Pawliczak, Rafal
Pniewska, Ewa
Zebrowska, Agnieszka
Wagrowska-Danilewicz, Malgorzata
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations.
Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production of coagulation factors in blistering diseases.
Skin biopsies were taken from 14 patients with DH, 27 with BP, and 20 control subjects.
The localization and expression of tissue factor (TF) in skin lesions and perilesional skin were studied by immunohistochemistry and confirmed by Western Blot.
Moreover the plasma concentrations of TF were measured by immunoassays.
D dimers, fibrinogen, and selected coagulation parameters were measured by routine methods.
Expression of TF in the epidermis and in inflammatory influxed cells in dermis was detected in skin biopsies from BP patients.
Examined TF expression was detected in perilesional skin of all BP patients too.
The expression of TF was not observed in biopsies from healthy people and DH patients.
The findings of the study show an increased expression of tissue factor in the lesional and perilesional skin of patients with bullous pemphigoid.
The difference in chemokine pattern expression and variations in the cellular infiltration in BP and DH cause variable expression of TF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zebrowska, Agnieszka& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Wieczfinska, Joanna& Pniewska, Ewa& Zebrowski, Michal…[et al.]. 2015. Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zebrowska, Agnieszka…[et al.]. Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zebrowska, Agnieszka& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Wieczfinska, Joanna& Pniewska, Ewa& Zebrowski, Michal…[et al.]. Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر