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Dexmedetomidine Ameliorate CLP-Induced Rat Intestinal Injury via Inhibition of Inflammation
المؤلفون المشاركون
Yao, Yusheng
Chen, Yanqing
Miao, Liyan
Wu, Weilan
Wu, Xiaodan
Gong, Cansheng
Qiu, Liangcheng
Chen, Jianping
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim was to verify that dexmedetomidine (DEX) can attenuate CLP-induced intestinal injury via inhibition of inflammation.
Male Sprague-Dawley (SD) rats were randomly allocated into Sham group and the other three CLP model groups, in terms of different treatments: placebo, DEX, and yohimbine plus DEX (DEX + YOH) groups.
Pathology examination was conducted with HE stain.
To identify differences among groups, the levels of DAO, and D-lactate in serum were measured by spectrophotometry, and the levels of TNF-α, IL-1β, and IL-6 in serum and organ were measured by ELISA.
The expressions of occludin and TLR4 in tissue were detected by Western blot.
The survival rate of an additional group of animals within 7 d was recorded.
In DEX group, mortality was lower, histology change was minor, DAO, and D-lactate levels were reduced, and occludin expression was increased; the expressions of TNF-α, IL-1β, IL-6, and TLR4 were also decreased in DEX group.
These results indicated that acute intestinal injury induced by CLP was mitigated by DEX treatment.
However, these effects of DEX were significantly attenuated by yohimbine in DEX + YOH group.
Our study indicated the protective effects of DEX on CLP-induced injury, which may be associated with the inhibition of inflammation via modulating TLR4 pathway and can be blocked by yohimbine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yanqing& Miao, Liyan& Yao, Yusheng& Wu, Weilan& Wu, Xiaodan& Gong, Cansheng…[et al.]. 2015. Dexmedetomidine Ameliorate CLP-Induced Rat Intestinal Injury via Inhibition of Inflammation. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072637
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yanqing…[et al.]. Dexmedetomidine Ameliorate CLP-Induced Rat Intestinal Injury via Inhibition of Inflammation. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072637
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yanqing& Miao, Liyan& Yao, Yusheng& Wu, Weilan& Wu, Xiaodan& Gong, Cansheng…[et al.]. Dexmedetomidine Ameliorate CLP-Induced Rat Intestinal Injury via Inhibition of Inflammation. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072637
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072637
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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