The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease
المؤلفون المشاركون
Elia, Paula Peruzzi
Tolentino, Yolanda Faia M.
de Souza, Heitor S.
Bernardazzi, Claudio
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Innate immunity constitutes the first line of defense, fundamental for the recognition and the initiation of an inflammatory response against microorganisms.
The innate immune response relies on the sensing of microbial-associated molecular patterns through specialized structures such as toll-like receptors (TLRs) and the nucleotide oligomerization domain- (NOD-) like receptors (NLRs).
In the gut, these tasks are performed by the epithelial barrier and the presence of adaptive and innate immune mechanisms.
TLRs and NLRs are distributed throughout the gastrointestinal mucosa, being more expressed in the epithelium, and in lamina propria immune and nonimmune cells.
These innate immunity receptors exhibit complementary biological functions, with evidence for pathways overlapping.
However, as tolerance is the predominant physiological response in the gastrointestinal mucosa, it appears that the TLRs are relatively downregulated, while NLRs play a critical role in mucosal defense in the gut.
Over the past two decades, genetic polymorphisms have been associated with several diseases including inflammatory bowel disease.
Special emphasis has been given to the susceptibility to Crohn’s disease, in association with abnormalities in the NOD2 and in the NLRP3/inflammasome.
Nevertheless, the mechanisms underlying innate immune receptors dysfunction that result in the persistent inflammation in inflammatory bowel disease remain to be clarified.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elia, Paula Peruzzi& Tolentino, Yolanda Faia M.& Bernardazzi, Claudio& de Souza, Heitor S.. 2015. The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elia, Paula Peruzzi…[et al.]. The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elia, Paula Peruzzi& Tolentino, Yolanda Faia M.& Bernardazzi, Claudio& de Souza, Heitor S.. The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر