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Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients
المؤلفون المشاركون
da Silva, João Santana
Silva, Marcelo José Barbosa
Cardoso, Cristina Ribeiro Barros
da Costa, Thiago Alvares
Alves, Polyanna Miranda
Chica, Javier Emílio Lazo
Barcelos, Emilio Zorzo
Giani, Max Antonio Alves
Rodrigues, Denise Bertulucci Rocha
Garlet, Gustavo Pompermaier
Rodrigues, Virmondes
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic periodontitis is a multifactorial inflammatory disease that affects supporting structures of the teeth.
Although the gingival response is largely described, little is known about the immune changes in the alveolar bone and neighboring tissues that could indicate periodontal disease (PD) activity.
Then, in this study we identified the ongoing inflammatory changes and novel biomarkers for periodontitis in the tissues directly affected by the destructive disease in PD patients.
Samples were collected by osteotomy in 17 control subjects during extraction of third molars and 18 patients with advanced PD, in which alveoloplasty was necessary after extraction of teeth with previous extensive periodontal damage.
Patients presented mononuclear cells infiltration in the connective tissue next to the bone and higher fibrosis area, along with increased accumulation of IL-17+ and TRAP+ cells.
The levels of TNF-α and MMP-2 mRNA were also elevated compared to controls and a positive and significant correlation was observed between TNF-α and MMP-2 mRNA expression, considering all samples evaluated.
In conclusion, nongingival tissues neighboring large periodontal pockets present inflammatory markers that could predict ongoing bone resorption and disease spreading.
Therefore, we suggested that the detailed evaluation of these regions could be of great importance to the assessment of disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Costa, Thiago Alvares& Silva, Marcelo José Barbosa& Alves, Polyanna Miranda& Chica, Javier Emílio Lazo& Barcelos, Emilio Zorzo& Giani, Max Antonio Alves…[et al.]. 2015. Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Costa, Thiago Alvares…[et al.]. Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Costa, Thiago Alvares& Silva, Marcelo José Barbosa& Alves, Polyanna Miranda& Chica, Javier Emílio Lazo& Barcelos, Emilio Zorzo& Giani, Max Antonio Alves…[et al.]. Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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