Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials
المؤلفون المشاركون
Bhargava, Pavan
Lang, Andrew
Al-Louzi, Omar
Carass, Aaron
Saidha, Shiv
Prince, Jerry L.
Calabresi, Peter A.
المصدر
Multiple Sclerosis International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The lack of segmentation algorithms operative across optical coherence tomography (OCT) platforms hinders utility of retinal layer measures in MS trials.
Objective.
To determine cross-sectional and longitudinal agreement of retinal layer thicknesses derived from an open-source, fully-automated, segmentation algorithm, applied to two spectral-domain OCT devices.
Methods.
Cirrus HD-OCT and Spectralis OCT macular scans from 68 MS patients and 22 healthy controls were segmented.
A longitudinal cohort comprising 51 subjects (mean follow-up: 1.4 ± 0.9 years) was also examined.
Bland-Altman analyses and interscanner agreement indices were utilized to assess agreement between scanners.
Results.
Low mean differences (−2.16 to 0.26 μm) and narrow limits of agreement (LOA) were noted for ganglion cell and inner and outer nuclear layer thicknesses cross-sectionally.
Longitudinally we found low mean differences (−0.195 to 0.21 μm) for changes in all layers, with wider LOA.
Comparisons of rate of change in layer thicknesses over time revealed consistent results between the platforms.
Conclusions.
Retinal thickness measures for the majority of the retinal layers agree well cross-sectionally and longitudinally between the two scanners at the cohort level, with greater variability at the individual level.
This open-source segmentation algorithm enables combining data from different OCT platforms, broadening utilization of OCT as an outcome measure in MS trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhargava, Pavan& Lang, Andrew& Al-Louzi, Omar& Carass, Aaron& Prince, Jerry L.& Calabresi, Peter A.…[et al.]. 2015. Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials. Multiple Sclerosis International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075271
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhargava, Pavan…[et al.]. Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials. Multiple Sclerosis International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075271
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhargava, Pavan& Lang, Andrew& Al-Louzi, Omar& Carass, Aaron& Prince, Jerry L.& Calabresi, Peter A.…[et al.]. Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials. Multiple Sclerosis International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075271
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075271
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر