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Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance
المؤلفون المشاركون
Cheung, Giselle
Sibille, Jérémie
Zapata, Jonathan
Rouach, Nathalie
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Recent evidence has shown that astrocytes play essential roles in synaptic transmission and plasticity.
Nevertheless, how neuronal activity alters astroglial functional properties and whether such properties also display specific forms of plasticity still remain elusive.
Here, we review research findings supporting this aspect of astrocytes, focusing on their roles in the clearance of extracellular potassium and glutamate, two neuroactive substances promptly released during excitatory synaptic transmission.
Their subsequent removal, which is primarily carried out by glial potassium channels and glutamate transporters, is essential for proper functioning of the brain.
Similar to neurons, different forms of short- and long-term plasticity in astroglial uptake have been reported.
In addition, we also present novel findings showing robust potentiation of astrocytic inward currents in response to repetitive stimulations at mild frequencies, as low as 0.75 Hz, in acute hippocampal slices.
Interestingly, neurotransmission was hardly affected at this frequency range, suggesting that astrocytes may be more sensitive to low frequency stimulation and may exhibit stronger plasticity than neurons to prevent hyperexcitability.
Taken together, these important findings strongly indicate that astrocytes display both short- and long-term plasticity in their clearance of excess neuroactive substances from the extracellular space, thereby regulating neuronal activity and brain homeostasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheung, Giselle& Sibille, Jérémie& Zapata, Jonathan& Rouach, Nathalie. 2015. Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance. Neural Plasticity،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheung, Giselle…[et al.]. Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance. Neural Plasticity No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1075290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheung, Giselle& Sibille, Jérémie& Zapata, Jonathan& Rouach, Nathalie. Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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