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Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone
المؤلفون المشاركون
Szegedi, Viktor
Horváth, János
Barkóczi, Balázs
Müller, Géza
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hippocampal oscillations recorded under urethane anesthesia are proposed to be modulated by anxiolytics.
All classes of clinically effective anxiolytics were reported to decrease the frequency of urethane theta; however, recent findings raise concerns about the direct correlation of anxiolysis and the frequency of hippocampal theta.
Here, we took advantage of our two inbred mouse strains displaying extremes of anxiety (anxious (AX) and nonanxious (nAX)) to compare the properties of hippocampal activity and to test the effect of an anxiolytic drugs.
No difference was observed in the peak frequency or in the peak power between AX and nAX strains.
Buspirone (Bus) applied in 2.5 mg/kg decreased anxiety of AX but did not have any effect on nAX as was tested by elevated plus maze and open field.
Interestingly, Bus treatment increased hippocampal oscillatory frequency in the AX but left it unaltered in nAX mice.
Saline injection did not have any effect on the oscillation.
Paired-pulse facilitation was enhanced by Bus in the nAX, but not in the AX strain.
Collectively, these results do not support the hypothesis that hippocampal activity under urethane may serve as a marker for potential anxiolytic drugs.
Moreover, we could not confirm the decrease of frequency after anxiolytic treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Horváth, János& Barkóczi, Balázs& Müller, Géza& Szegedi, Viktor. 2015. Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone. Neural Plasticity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Horváth, János…[et al.]. Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone. Neural Plasticity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Horváth, János& Barkóczi, Balázs& Müller, Géza& Szegedi, Viktor. Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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