Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG
المؤلفون المشاركون
Han, Wenjuan
Zhang, Ming
Zheng, Jianyong
Meng, Fancheng
Jiao, Xiying
Hu, Sanjue
Xu, Hui
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Recently several lines of evidence demonstrated that methylcobalamin (MeCbl) might have potential analgesic effect in experimental and clinical studies.
However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain.
Thus, the effects of short-term and long-term administration of MeCbl were examined in the chronic compression of dorsal root ganglion (CCD) model.
We found that mechanical allodynia was significantly inhibited by a continuous application of high dose and a single treatment of a super high dose of MeCbl.
Little is known about mechanisms underlying the analgesia of MeCbl.
We examined the effect of MeCbl on the spontaneous activity (SA), the excitability, and hyperpolarization-activated nonselective cation ion current in compressed medium-sized dorsal root ganglion (DRG) neurons using extracellular single fiber recording in vivo and whole-cell patch clamp in vitro.
We found that MeCbl significantly inhibited the SA of A-type sensory neurons in a dose-dependent manner and inhibited the excitability of medium-sized DRG neurons.
In addition, MeCbl also decreased I h current density in injured medium-sized DRG neurons.
Our results proved that MeCbl might exert an analgesic effect through the inhibition I h current and then might inhibit the hyperexcitability of primary sensory neurons under neuropathic pain state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Ming& Han, Wenjuan& Zheng, Jianyong& Meng, Fancheng& Jiao, Xiying& Hu, Sanjue…[et al.]. 2015. Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG. Neural Plasticity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075306
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Ming…[et al.]. Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG. Neural Plasticity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075306
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Ming& Han, Wenjuan& Zheng, Jianyong& Meng, Fancheng& Jiao, Xiying& Hu, Sanjue…[et al.]. Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075306
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075306
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر