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Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses
المؤلف
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The relevance of neuronal and synaptic variability remains unclear.
Cellular and synaptic plasticity and neuromodulation are also variable.
This could reflect state-dependent effects caused by the variable initial cellular or synaptic properties or direct variability in plasticity-inducing mechanisms.
This study has examined state-dependent influences on synaptic plasticity at connections between excitatory interneurons (EIN) and motor neurons in the lamprey spinal cord.
State-dependent effects were examined by correlating initial synaptic properties with the substance P-mediated plasticity of low frequency-evoked EPSPs and the reduction of the EPSP depression over spike trains (metaplasticity).
The low frequency EPSP potentiation reflected an interaction between the potentiation of NMDA responses and the release probability.
The release probability introduced a variable state-dependent subtractive influence on the postsynaptic NMDA-dependent potentiation.
The metaplasticity was also state-dependent: it was greater at connections with smaller available vesicle pools and high initial release probabilities.
This was supported by the significant reduction in the number of connections showing metaplasticity when the release probability was reduced by high Mg2+ Ringer.
Initial synaptic properties thus introduce state-dependent influences that affect the potential for plasticity.
Understanding these conditions will be as important as understanding the subsequent changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parker, David. 2015. Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses. Neural Plasticity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parker, David. Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses. Neural Plasticity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parker, David. Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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