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Clinical Trial of Human Fetal Brain-Derived Neural StemProgenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
المؤلفون المشاركون
Park, Kook In
Shin, Ji Cheol
Kim, Keung Nyun
Yoo, Jeehyun
Kim, Il-Sun
Yun, Seokhwan
Lee, Hyejin
Jung, Kwangsoo
Hwang, Kyujin
Kim, Miri
Lee, Il-Shin
Shin, Jeong Eun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI).
Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete.
hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord.
In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included.
At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity.
The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B).
Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group.
Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants.
This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shin, Ji Cheol& Kim, Keung Nyun& Yoo, Jeehyun& Kim, Il-Sun& Yun, Seokhwan& Lee, Hyejin…[et al.]. 2015. Clinical Trial of Human Fetal Brain-Derived Neural StemProgenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury. Neural Plasticity،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1075380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shin, Ji Cheol…[et al.]. Clinical Trial of Human Fetal Brain-Derived Neural StemProgenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury. Neural Plasticity No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1075380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shin, Ji Cheol& Kim, Keung Nyun& Yoo, Jeehyun& Kim, Il-Sun& Yun, Seokhwan& Lee, Hyejin…[et al.]. Clinical Trial of Human Fetal Brain-Derived Neural StemProgenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1075380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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