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Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
المؤلفون المشاركون
D’Aleo, Giangaetano
Rifici, Carmela
Russo, Margherita
Sessa, Edoardo
Naro, Antonino
Leo, Antonino
De Luca, Rosaria
Quartarone, Angelo
Bramanti, Placido
Calabrò, Rocco Salvatore
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Sativex is an emergent treatment option for spasticity in patients affected by multiple sclerosis (MS).
This oromucosal spray, acting as a partial agonist at cannabinoid receptors, may modulate the balance between excitatory and inhibitory neurotransmitters, leading to muscle relaxation that is in turn responsible for spasticity improvement.
Nevertheless, since the clinical assessment may not be sensitive enough to detect spasticity changes, other more objective tools should be tested to better define the real drug effect.
The aim of our study was to investigate the role of Sativex in improving spasticity and related symptomatology in MS patients by means of an extensive neurophysiological assessment of sensory-motor circuits.
To this end, 30 MS patients underwent a complete clinical and neurophysiological examination, including the following electrophysiological parameters: motor threshold, motor evoked potentials amplitude, intracortical excitability, sensory-motor integration, and Hmax/Mmax ratio.
The same assessment was applied before and after one month of continuous treatment.
Our data showed an increase of intracortical inhibition, a significant reduction of spinal excitability, and an improvement in spasticity and associated symptoms.
Thus, we can speculate that Sativex could be effective in reducing spasticity by means of a double effect on intracortical and spinal excitability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Russo, Margherita& Calabrò, Rocco Salvatore& Naro, Antonino& Sessa, Edoardo& Rifici, Carmela& D’Aleo, Giangaetano…[et al.]. 2015. Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation. Neural Plasticity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Russo, Margherita…[et al.]. Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation. Neural Plasticity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Russo, Margherita& Calabrò, Rocco Salvatore& Naro, Antonino& Sessa, Edoardo& Rifici, Carmela& D’Aleo, Giangaetano…[et al.]. Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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