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Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus
المؤلفون المشاركون
Savotchenko, Alina
Romanov, Arthur
Isaev, Dmytro
Maximyuk, Oleksandr
Sydorenko, Vadym
Holmes, Gregory L.
Isaeva, Elena
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neuraminidase (NEU) is a key enzyme that cleaves negatively charged sialic acid residues from membrane proteins and lipids.
Clinical and basic science studies have shown that an imbalance in NEU metabolism or changes in NEU activity due to various pathological conditions parallel with behavior and cognitive impairment.
It has been suggested that the decreases of NEU activity could cause serious neurological consequences.
However, there is a lack of direct evidences that modulation of endogenous NEU activity can impair neuronal function.
Using combined rat entorhinal cortex/hippocampal slices and a specific inhibitor of NEU, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NADNA), we examined the effect of downregulation of NEU activity on different forms of synaptic plasticity in the hippocampal CA3-to-CA1 network.
We show that NEU inhibition results in a significant decrease in long-term potentiation (LTP) and an increase in short-term depression.
Synaptic depotentiation restores LTP in NADNA-pretreated slices to the control level.
These data suggest that short-term NEU inhibition produces the LTP-like effect on neuronal network, which results in damping of further LTP induction.
Our findings demonstrate that downregulation of NEU activity could have a major impact on synaptic plasticity and provide a new insight into the cellular mechanism underlying behavioral and cognitive impairment associated with abnormal metabolism of NEU.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Savotchenko, Alina& Romanov, Arthur& Isaev, Dmytro& Maximyuk, Oleksandr& Sydorenko, Vadym& Holmes, Gregory L.…[et al.]. 2015. Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Savotchenko, Alina…[et al.]. Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Savotchenko, Alina& Romanov, Arthur& Isaev, Dmytro& Maximyuk, Oleksandr& Sydorenko, Vadym& Holmes, Gregory L.…[et al.]. Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075425
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