Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide
المؤلفون المشاركون
Azizi-Malekabadi, Hamid
Pourganji, Masoume
Zabihi, Hoda
Saeedjalali, Mohsen
Anaeigoudari, Akbar
Hosseini, Mahmoud
المصدر
Neurology Research International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors.
The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered.
In the present study, the capability of deletion of ovarian hormones to induce sickness-like behaviors in rats was compared with the effect lipopolysaccharide (LPS).
The groups were including Sham, OVX, Sham-LPS, and OVX-LPS.
The Sham-LPS and OVX-LPS groups were treated with LPS (250 μg/kg) two hours before conducting the behavioral tests.
In the forced swimming (FST), the immobility times in both OVX and Sham-LPS groups were higher than that of Sham ( P < 0.001 ).
In open-field (OP) test, the central crossing number by OVX and Sham-LPS groups were lower than Sham ( P < 0.001 ) while there were no significant differences between OVX-LPS and OVX groups.
In elevated plus maze (EPM), the percent of entries to the open arm by both OVX and Sham-LPS groups was lower than that of Sham group ( P < 0.001 ).
The results of present study showed that deletion of ovarian hormones induced sickness behaviors in rats which were comparable to the effects of LPS.
Moreover, further investigations are required in order to better understand the mechanism(s) involved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azizi-Malekabadi, Hamid& Hosseini, Mahmoud& Pourganji, Masoume& Zabihi, Hoda& Saeedjalali, Mohsen& Anaeigoudari, Akbar. 2015. Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide. Neurology Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azizi-Malekabadi, Hamid…[et al.]. Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide. Neurology Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azizi-Malekabadi, Hamid& Hosseini, Mahmoud& Pourganji, Masoume& Zabihi, Hoda& Saeedjalali, Mohsen& Anaeigoudari, Akbar. Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide. Neurology Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر