High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac IschemiaReperfusion Injury due to Induction of Oxidative Damage in Coronary Artery
المؤلفون المشاركون
Yang, Qian
Wu, Wei
Li, Qian
Chen, Chan
Zhou, Ronghua
Qiu, Yanhua
Luo, Ming
Tan, Zhaoxia
Li, Shen
Chen, Gang
Zhou, Wentao
Liu, Jiaxin
Yang, Chengmin
Liu, Jin
Li, Tao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Ischemia/reperfusion (I/R) injury is an unavoidable event for patients in cardiac surgery under cardiopulmonary bypass (CPB).
This study was designed to investigate whether glutaraldehyde-polymerized human placenta hemoglobin (PolyPHb), a hemoglobin-based oxygen carrier (HBOC), can protect heart against CPB-induced I/R injury or not and to elucidate the underlying mechanism.
Methods and Results.
A standard dog CPB model with 2-hour cardiac arrest and 2-hour reperfusion was established.
The results demonstrated that a low-dose PolyPHb (0.1%, w/v) provided a significant protection on the I/R heart, whereas the high-dose PolyPHb (3%, w/v) did not exhibit cardioprotective effect, as evidenced by the impaired cardiac function, decreased myocardial oxygen utilization, and elevated enzymes release and pathological changes.
Further study indicated that exposure of isolated coronary arteries or human umbilical vein endothelial cells (HUVECs) to a high-dose PolyPHb caused impaired endothelium-dependent relaxation, which was companied with increased reactive oxygen species (ROS) production, reduced superoxide dismutase (SOD) activity, and elevated malonaldehyde (MDA) formation.
Consistent with the increased oxidative stress, the NAD(P)H oxidase activity and subunits expression, including gp91phox, p47phox, p67phox, and Nox1, were greatly upregulated.
Conclusion.
The high-dose PolyPHb fails to protect heart from CPB-induced I/R injury, which was due to overproduction of NAD(P)H oxidase-induced ROS and resultant endothelial dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Qian& Wu, Wei& Li, Qian& Chen, Chan& Zhou, Ronghua& Qiu, Yanhua…[et al.]. 2015. High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac IschemiaReperfusion Injury due to Induction of Oxidative Damage in Coronary Artery. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Qian…[et al.]. High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac IschemiaReperfusion Injury due to Induction of Oxidative Damage in Coronary Artery. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Qian& Wu, Wei& Li, Qian& Chen, Chan& Zhou, Ronghua& Qiu, Yanhua…[et al.]. High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac IschemiaReperfusion Injury due to Induction of Oxidative Damage in Coronary Artery. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر