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Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain
المؤلفون المشاركون
Mitcheva, Mitka
Simeonova, Rumyana
Kondeva-Burdina, Magdalena
Vitcheva, Vessela
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
One of the mechanisms involved in the development of addiction, as well as in brain toxicity, is the oxidative stress.
The aim of the current study was to investigate the effects of 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric oxide synthase (nNOS), on cocaine withdrawal and neurotoxicity in male Wistar rats.
The animals were divided into four groups: control; group treated with cocaine (15 mg/kg−1, i.p., 7 days); group treated with 7-NI (25 mg/kg−1, i.p., 7 days); and a combination group (7-NI + cocaine).
Cocaine repeated treatment resulted in development of physical dependence, judged by withdrawal symptoms (decreased locomotion, increased salivation and breathing rate), accompanied by an increased nNOS activity and oxidative stress.
The latter was discerned by an increased formation of malondialdehyde (MDA), depletion of reduced glutathione (GSH) levels, and impairment of the enzymatic antioxidant defense system measured in whole brain.
In synaptosomes, isolated from cocaine-treated rats, mitochondrial activity and GSH levels were also decreased.
7-NI administered along with cocaine not only attenuated the withdrawal, due to its nNOS inhibition, but also reversed both the GSH levels and antioxidant enzyme activities near control levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vitcheva, Vessela& Simeonova, Rumyana& Kondeva-Burdina, Magdalena& Mitcheva, Mitka. 2015. Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vitcheva, Vessela…[et al.]. Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vitcheva, Vessela& Simeonova, Rumyana& Kondeva-Burdina, Magdalena& Mitcheva, Mitka. Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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