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High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage
المؤلفون المشاركون
Gergely, Szabolcs
Hegedűs, Csaba
Lakatos, Petra
Kovács, Katalin
Gáspár, Renáta
Csont, Tamás
Virág, L.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Antracyclines are effective antitumor agents.
One of the most commonly used antracyclines is doxorubicin, which can be successfully used to treat a diverse spectrum of tumors.
Application of these drugs is limited by their cardiotoxic effect, which is determined by a lifetime cumulative dose.
We set out to identify by high throughput screening cardioprotective compounds protecting cardiomyocytes from doxorubicin-induced injury.
Ten thousand compounds of ChemBridge’s DIVERSet compound library were screened to identify compounds that can protect H9C2 rat cardiomyocytes against doxorubicin-induced cell death.
The most effective compound proved protective in doxorubicin-treated primary rat cardiomyocytes and was further characterized to demonstrate that it significantly decreased doxorubicin-induced apoptotic and necrotic cell death and inhibited doxorubicin-induced activation of JNK MAP kinase without having considerable radical scavenging effect or interfering with the antitumor effect of doxorubicin.
In fact the compound identified as 3-[2-(4-ethylphenyl)-2-oxoethyl]-1,2-dimethyl-1H-3,1-benzimidazol-3-ium bromide was toxic to all tumor cell lines tested even without doxorubicine treatment.
This benzimidazole compound may lead, through further optimalization, to the development of a drug candidate protecting the heart from doxorubicin-induced injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gergely, Szabolcs& Hegedűs, Csaba& Lakatos, Petra& Kovács, Katalin& Gáspár, Renáta& Csont, Tamás…[et al.]. 2015. High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gergely, Szabolcs…[et al.]. High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gergely, Szabolcs& Hegedűs, Csaba& Lakatos, Petra& Kovács, Katalin& Gáspár, Renáta& Csont, Tamás…[et al.]. High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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