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Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage
المؤلفون المشاركون
Miller, Elżbieta
Morel, Agnieszka
Bijak, Michał
Rywaniak, Joanna
Miller, Sergiusz
Saluk, Joanna
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) is the autoimmune disease of the central nervous system with complex pathogenesis, different clinical courses and recurrent neurological relapses and/or progression.
Despite various scientific papers that focused on early stage of MS, our study targets selective group of late stage secondary progressive MS patients.
The presented work is concerned with the reactivity of blood platelets in primary hemostasis in SP MS patients.
50 SP MS patients and 50 healthy volunteers (never diagnosed with MS or other chronic diseases) were examined to evaluate the biological activity of blood platelets (adhesion, aggregation), especially their response to the most important physiological agonists (thrombin, ADP, and collagen) and the effect of oxidative stress on platelet activity.
We found that the blood platelets from SP MS patients were significantly more sensitive to all used agonists in comparison with control group.
Moreover, the platelet hemostatic function was advanced in patients suffering from SP MS and positively correlated with increased production of O 2 - ∙ in these cells, as well as with Expanded Disability Status Scale.
We postulate that the increased oxidative stress in blood platelets in SP MS may be primarily responsible for the altered haemostatic properties of blood platelets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morel, Agnieszka& Bijak, Michał& Miller, Elżbieta& Rywaniak, Joanna& Miller, Sergiusz& Saluk, Joanna. 2015. Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morel, Agnieszka…[et al.]. Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morel, Agnieszka& Bijak, Michał& Miller, Elżbieta& Rywaniak, Joanna& Miller, Sergiusz& Saluk, Joanna. Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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