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Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Wang, Shuxia
Song, Kangxing
Qi, Dake
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Mitochondrial permeability transition pore (mPTP) opening due to its role in regulating ROS generation contributes to cardiac reperfusion injury.
In animals, cyclosporine (cyclosporine A, CsA), an inhibitor of mPTP, has been found to prevent reperfusion injury following acute myocardial infarction.
However, the effects of CsA in reperfusion injury in clinical patients are not elucidated.
We performed a meta-analysis using published clinical studies and electronic databases.
Relevant data were extracted using standardized algorithms and additional data were obtained directly from investigators as indicated.
Five randomized controlled blind trials were included in our meta-analysis.
The clinical outcomes including infarct size (SMD: −0.41; 95% CI: −0.81, 0.01; P = 0.058), left ventricular ejection fraction (LVEF) (SMD: 0.20; 95% CI: −0.02, 0.42; P = 0.079), troponin I (TnI) (SMD: −0.21; 95% CI: −0.49, 0.07; P = 0.149), creatine kinase (CK) (SMD: −0.32; 95% CI: −0.98, 0.35; P = 0.352), and creatine kinase-MB isoenzyme (CK-MB) (SMD: −0.06; 95% CI: −0.35, 0.23; P = 0.689) suggested that there is no significant difference on cardiac function and injury with or without CsA treatment.
Our results indicated that, unlike the positive effects of CsA in animal models, CsA administration may not protect heart from reperfusion injury in clinical patients with myocardial infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Kangxing& Wang, Shuxia& Qi, Dake. 2015. Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075579
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Kangxing…[et al.]. Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075579
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Kangxing& Wang, Shuxia& Qi, Dake. Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075579
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075579
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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