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Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives
المؤلفون المشاركون
Solís-Calero, Christian
Ortega-Castro, Joaquín
Frau, Juan
Muñoz, Francisco
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-21
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Phospholipids play multiple and essential roles in cells, as components of biological membranes.
Although phospholipid bilayers provide the supporting matrix and surface for many enzymatic reactions, their inherent reactivity and possible catalytic role have not been highlighted.
As other biomolecules, phospholipids are frequent targets of nonenzymatic modifications by reactive substances including oxidants and glycating agents which conduct to the formation of advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs).
There are some theoretical studies about the mechanisms of reactions related to these processes on phosphatidylethanolamine surfaces, which hypothesize that cell membrane phospholipids surface environment could enhance some reactions through a catalyst effect.
On the other hand, the phospholipid bilayers are susceptible to oxidative damage by oxidant agents as reactive oxygen species (ROS).
Molecular dynamics simulations performed on phospholipid bilayers models, which include modified phospholipids by these reactions and subsequent reactions that conduct to formation of ALEs and AGEs, have revealed changes in the molecular interactions and biophysical properties of these bilayers as consequence of these reactions.
Then, more studies are desirable which could correlate the biophysics of modified phospholipids with metabolism in processes such as aging and diseases such as diabetes, atherosclerosis, and Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Solís-Calero, Christian& Ortega-Castro, Joaquín& Frau, Juan& Muñoz, Francisco. 2015. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1075589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Solís-Calero, Christian…[et al.]. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1075589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Solís-Calero, Christian& Ortega-Castro, Joaquín& Frau, Juan& Muñoz, Francisco. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1075589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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