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Poststroke Depression as a Factor Adversely Affecting the Level of Oxidative Damage to Plasma Proteins during a Brain Stroke
المؤلفون المشاركون
Miller, Elżbieta
Saluk, Joanna
Cichoń, Natalia
Bijak, Michał
Niwald, Marta
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Poststroke depression, the second most serious psychosomatic complication after brain stroke, leads to delay of the rehabilitation process and is associated with an increased disability and cognitive impairment along with increase in term mortality.
Research into the biochemical changes in depression is still insufficiently described.
The aim of our study was therefore to evaluate the possible association between plasma protein oxidative/nitrative damages and the development of poststroke depression.
We evaluated oxidative/nitrative modifications of specific proteins by measurement of 3-nitrotyrosine and carbonyl groups levels using ELISA test.
Additionally, we checked differences in proteins thiol groups by spectrophotometric assay based on reaction between DTNB and thiols.
We also evaluated catalase activity in erythrocytes measured as ability to decompose H2O2.
Correlation analysis was performed using Spearman’s rank.
We observed significant ( P < 0.001 ) differences in all oxidative/nitrative stress parameters in brain stroke patients compared to healthy group.
Our research shows that oxidative damage of proteins is correlated with the degree of poststroke depression, while nitrative changes do not show any relationship.
We demonstrate a positive correlation between the concentration of carbonyl groups and the Geriatric Depression Scale and a negative correlation between the degree of depression and the concentration of -SH groups or catalase activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cichoń, Natalia& Bijak, Michał& Miller, Elżbieta& Niwald, Marta& Saluk, Joanna. 2015. Poststroke Depression as a Factor Adversely Affecting the Level of Oxidative Damage to Plasma Proteins during a Brain Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075641
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cichoń, Natalia…[et al.]. Poststroke Depression as a Factor Adversely Affecting the Level of Oxidative Damage to Plasma Proteins during a Brain Stroke. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075641
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cichoń, Natalia& Bijak, Michał& Miller, Elżbieta& Niwald, Marta& Saluk, Joanna. Poststroke Depression as a Factor Adversely Affecting the Level of Oxidative Damage to Plasma Proteins during a Brain Stroke. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075641
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075641
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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