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Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice
المؤلفون المشاركون
Yu, Weifeng
Chen, Jiaying
Wu, Feixiang
Long, Yue
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We investigated the protective effects and mechanism of glutathione (GSH) on vascular hyporesponsiveness induced by bile duct ligation (BDL) in a rat model.
Seventy-two male Sprague-Dawley rats were randomly divided into four groups: a NS group, a GSH group, a BDL + NS group, and a BDL + GSH group.
GSH was administrated into rats in the GSH and BDL + GSH groups by gastric gavage.
An equal volume of normal saline was, respectively, given in the NS group and BDL + NS group.
Blood was gathered for serological determination and thoracic aorta rings were isolated for measurement of isometric tension.
Obstructive jaundice led to a significant increase in the serum total bilirubin, AST, and ALT levels.
The proinflammatory cytokines levels (TNF-α and IL-1β), concentration of NO, and oxidative stress markers (MDA and 3-NT) were increased as well.
All of those were reduced by the treatment of GSH.
Meanwhile, contraction of aorta rings to NA and vasorelaxation to ACh or SNP in the BDL group rats were markedly decreased, while GSH administration reversed this change.
Our findings suggested that GSH supplementation attenuated overexpressed ONOO(−) from the reaction of excessive NO with O 2 ∙- and protected against obstructive jaundice-induced vascular hyporesponsiveness in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jiaying& Wu, Feixiang& Long, Yue& Yu, Weifeng. 2015. Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075669
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jiaying…[et al.]. Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075669
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jiaying& Wu, Feixiang& Long, Yue& Yu, Weifeng. Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075669
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075669
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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