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Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases
المؤلفون المشاركون
Yang, Se-Ran
Park, Jeong-Ran
Kang, Kyung-Sun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
MSCs have become an emerging cell source with their immune modulation, high proliferation rate, and differentiation potential; indeed, they have been challenged in clinical trials.
Recently, it has shown that ROS play a dual role as both deleterious and beneficial species depending on their concentration in MSCs.
Various environmental stresses-induced excessive production of ROS triggers cellular senescence and abnormal differentiation on MSCs.
Moreover, MSCs have been suggested to participate in the treatment of ALI/ARDS and COPD as a major cause of high morbidity and mortality.
Therapeutic mechanisms of MSCs in the treatment of ARDS/COPD were focused on cell engraftment and paracrine action.
However, ROS-mediated therapeutic mechanisms of MSCs still remain largely unknown.
Here, we review the key factors associated with cell cycle and chromatin remodeling to accelerate or delay the MSC aging process.
In addition, the enhanced ROS production and its associated pathophysiological pathways will be discussed along with the MSC senescence process.
Furthermore, the present review highlights how the excessive amount of ROS-mediated oxidative stress might interfere with homeostasis of lungs and residual lung cells in the pathogenesis of ALI/ARDS and COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Se-Ran& Park, Jeong-Ran& Kang, Kyung-Sun. 2015. Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Se-Ran…[et al.]. Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Se-Ran& Park, Jeong-Ran& Kang, Kyung-Sun. Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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