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Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21
المؤلفون المشاركون
Rodríguez-Sureda, Víctor
Vilches, Ángel
Sánchez, Olga
Audí, Laura
Domínguez, Carmen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Down’s syndrome (DS) is characterized by a complex phenotype associated with chronic oxidative stress and mitochondrial dysfunction.
Overexpression of genes on chromosome-21 is thought to underlie the pathogenesis of the major phenotypic features of DS, such as premature aging.
Using cultured fibroblasts with trisomy 21 (T21F), this study aimed to ascertain whether an imbalance exists in activities, mRNA, and protein expression of the antioxidant enzymes SOD1, SOD2, glutathione-peroxidase, and catalase during the cell replication process in vitro.
T21F had high SOD1 expression and activity which led to an interenzymatic imbalance in the antioxidant defense system, accentuated with replicative senescence.
Intracellular ROS production and oxidized protein levels were significantly higher in T21F compared with control cells; furthermore, a significant decline in intracellular ATP content was detected in T21F.
Cell senescence was found to appear prematurely in DS cells as shown by SA-β-Gal assay and p21 assessment, though not apoptosis, as neither p53 nor the proapoptotic proteins cytochrome c and caspase 9 were altered in T21F.
These novel findings would point to a deleterious role of oxidatively modified molecules in early cell senescence of T21F, thereby linking replicative and stress-induced senescence in cultured cells to premature aging in DS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodríguez-Sureda, Víctor& Vilches, Ángel& Sánchez, Olga& Audí, Laura& Domínguez, Carmen. 2015. Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodríguez-Sureda, Víctor…[et al.]. Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodríguez-Sureda, Víctor& Vilches, Ángel& Sánchez, Olga& Audí, Laura& Domínguez, Carmen. Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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