Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State
المؤلفون المشاركون
Kalpravidh, Ruchaneekorn W.
Hatairaktham, Suneerat
Charoensakdi, Ratiya
Panichkul, Narumol
Siritanaratkul, Noppadol
Yanpanitch, Orn-uma
Fucharoen, Suthat
Srichairatanakool, Somdet
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Studies on the antioxidant treatment for thalassemia have reported variable outcomes.
However, treatment of thalassemia with a combination of hydrophobic and hydrophilic antioxidants and an iron chelator has not been studied.
This study investigated the effects of antioxidant cocktails for the treatment of β-thalassemia/hemoglobin E (HbE), which is the most common form of β-thalassemia in Southeast Asia.
Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, and either curcuminoids (CUR) or vitamin E (Vit-E), and their hematological parameters, iron load, oxidative stress, and blood coagulation potential were evaluated.
Patients were classified as responders if they showed the improvements of the markers of iron load and oxidative stress, otherwise as nonresponders.
During treatment, the responders in both groups had significantly decreased iron load, oxidative stress, and coagulation potential and significantly increased antioxidant capacity and hemoglobin concentration.
The significantly maximum increase (P<0.01) in hemoglobin concentration was 11% at month 4 in CUR group responders and 10% at month 10 in Vit-E group responders.
In conclusion, the two antioxidant cocktails can improve anemia, iron overload, oxidative stress, and hypercoagulable state in β-thalassemia/HbE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yanpanitch, Orn-uma& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Fucharoen, Suthat& Srichairatanakool, Somdet…[et al.]. 2015. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yanpanitch, Orn-uma…[et al.]. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yanpanitch, Orn-uma& Hatairaktham, Suneerat& Charoensakdi, Ratiya& Panichkul, Narumol& Fucharoen, Suthat& Srichairatanakool, Somdet…[et al.]. Treatment of β-ThalassemiaHemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر