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Protective Effects of the Flavonoid Chrysin against Methylmercury-Induced Genotoxicity and Alterations of Antioxidant Status, In Vivo
المؤلفون المشاركون
Bastos, Jairo Kennup
Antunes, Lusânia Maria Greggi
Manzolli, Eduardo Scandinari
Serpeloni, Juliana Mara
Barcelos, Gustavo Rafael Mazzaron
Barbosa Junior, Fernando
Grotto, Denise
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The use of phytochemicals has been widely used as inexpensive approach for prevention of diseases related to oxidative damage due to its antioxidant properties.
One of dietary flavonoids is chrysin (CR), found mainly in passion fruit, honey, and propolis.
Methylmercury (MeHg) is a toxic metal whose main toxic mechanism is oxidative damage.
Thus, the study aimed to evaluate the antioxidant effects of CR against oxidative damage induced by MeHg in Wistar rats.
Animals were treated with MeHg (30 µg/kg/bw) in presence and absence of CR (0.10, 1.0, and 10 mg/kg/bw) by gavage for 45 days.
Glutathione (GSH) in blood was quantified spectrophotometrically and for monitoring of DNA damage, comet assay was used in leukocytes and hepatocytes.
MeHg led to a significant increase in the formation of comets; when the animals were exposed to the metal in the presence of CR, higher concentrations of CR showed protective effects.
Moreover, exposure to MeHg decreased the levels of GSH and GSH levels were restored in the animals that received CR plus MeHg.
Taken together the findings of the present work indicate that consumption of flavonoids such as CR may protect humans against the adverse health effects caused by MeHg.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manzolli, Eduardo Scandinari& Serpeloni, Juliana Mara& Grotto, Denise& Bastos, Jairo Kennup& Antunes, Lusânia Maria Greggi& Barbosa Junior, Fernando…[et al.]. 2015. Protective Effects of the Flavonoid Chrysin against Methylmercury-Induced Genotoxicity and Alterations of Antioxidant Status, In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manzolli, Eduardo Scandinari…[et al.]. Protective Effects of the Flavonoid Chrysin against Methylmercury-Induced Genotoxicity and Alterations of Antioxidant Status, In Vivo. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manzolli, Eduardo Scandinari& Serpeloni, Juliana Mara& Grotto, Denise& Bastos, Jairo Kennup& Antunes, Lusânia Maria Greggi& Barbosa Junior, Fernando…[et al.]. Protective Effects of the Flavonoid Chrysin against Methylmercury-Induced Genotoxicity and Alterations of Antioxidant Status, In Vivo. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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