Hsp20 Protects against Oxygen-Glucose DeprivationReperfusion-Induced Golgi Fragmentation and Apoptosis through FasFasL Pathway
المؤلفون المشاركون
Zhong, Bingwu
Tan, Jieqiong
Lu, Tonglin
Lei, Qiang
Chen, Chunli
Zeng, Liuwang
Hu, Zhiping
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cerebral ischemia-reperfusion injury plays an important role in the development of tissue injury after acute ischemic stroke.
Finding effective neuroprotective agents has become a priority in the treatment of ischemic stroke.
The Golgi apparatus (GA) is a pivotal organelle and its protection is an attractive target in the treatment of cerebral ischemia-reperfusion injury.
Protective effects of Hsp20, a potential cytoprotective agent due to its chaperone-like activity and involvement in regulation of many vital processes, on GA were assessed in an ischemia-reperfusion injury model.
Mouse neuroblastoma Neuro2a (N2a) cells were subjected to oxygen-glucose deprivation/reperfusion (OGDR) insult.
OGDR induces Golgi fragmentation, apoptosis, and p115 cleavage in N2a cells.
However, transfection with Hsp20 significantly attenuates OGDR-induced Golgi fragmentation and apoptosis.
Hsp20 interacts with Bax, decreases FasL and Bax expression, and inhibits caspases 3 and p115 cleavage in N2a cells exposed to OGDR.
Our data demonstrate that increased Hsp20 expression protects against OGDR-induced Golgi fragmentation and apoptosis, likely through interaction with Bax and subsequent amelioration of the OGDR-induced elevation in p115 cleavage via the Fas/FasL signaling pathway.
This neuroprotective potential of Hsp20 against OGDR insult and the underlying mechanism will pave the way for its potential clinical application for cerebral ischemia-reperfusion related disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Bingwu& Hu, Zhiping& Tan, Jieqiong& Lu, Tonglin& Lei, Qiang& Chen, Chunli…[et al.]. 2015. Hsp20 Protects against Oxygen-Glucose DeprivationReperfusion-Induced Golgi Fragmentation and Apoptosis through FasFasL Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Bingwu…[et al.]. Hsp20 Protects against Oxygen-Glucose DeprivationReperfusion-Induced Golgi Fragmentation and Apoptosis through FasFasL Pathway. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Bingwu& Hu, Zhiping& Tan, Jieqiong& Lu, Tonglin& Lei, Qiang& Chen, Chunli…[et al.]. Hsp20 Protects against Oxygen-Glucose DeprivationReperfusion-Induced Golgi Fragmentation and Apoptosis through FasFasL Pathway. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر