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Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes
المؤلفون المشاركون
de Almeida, Eduardo A.
Gobbo, Marina G.
Góes, Rejane M.
Costa, Carolina F. Pereira
Silva, Danilo G. Humberto
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study investigated the antioxidant system response of male reproductive organs during early and late phases of diabetes and the influence of melatonin treatment.
Melatonin was administered to five-week-old Wistar rats throughout the experiment, in drinking water (10 μg/kg b.w).
Diabetes was induced at 13 weeks of age by streptozotocin (4.5 mg/100 g b.w., i.p.) and animals were euthanized with 14 or 21 weeks old.
Activities of catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), and lipid peroxidation were evaluated in prostate, testis, and epididymis.
The enzymes activities and lipid peroxidation were not affected in testis and epididymis after one or eight weeks of diabetes.
Prostate exhibited a 3-fold increase in GPx activity at short-term diabetes and at long-term diabetes there were 2- and 3-fold increase in CAT and GST, respectively (p≤0.01).
Melatonin treatment to healthy rats caused a 47% increase in epididymal GPx activity in 14-week-old rats.
In prostate, melatonin administration normalized GST activity at both ages and mitigated GPx at short-term and CAT at long-term diabetes.
The testis and epididymis were less affected by diabetes than prostate.
Furthermore, melatonin normalized the enzymatic disorders in prostate demonstrating its effective antioxidant role, even at low dosages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gobbo, Marina G.& Costa, Carolina F. Pereira& Silva, Danilo G. Humberto& de Almeida, Eduardo A.& Góes, Rejane M.. 2015. Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gobbo, Marina G.…[et al.]. Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gobbo, Marina G.& Costa, Carolina F. Pereira& Silva, Danilo G. Humberto& de Almeida, Eduardo A.& Góes, Rejane M.. Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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