Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits
المؤلفون المشاركون
Huang, Weihua
Xu, Yao
Xia, Zhengyuan
Ma, Songmei
Liu, Bingbing
Xiao, Xiaoshan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ulinastatin (UTI), a trypsin inhibitor, is isolated and purified from human urine and has been shown to exert protective effect on myocardial ischemia reperfusion injury in patients.
The present study was aimed at investigating the effect of ulinastatin on neurologic functions after spinal cord ischemia reperfusion injury and the underlying mechanism.
The spinal cord IR model was achieved by occluding the aorta just caudal to the left renal artery with a bulldog clamp.
The drugs were administered immediately after the clamp was removed.
The animals were terminated 48 hours after reperfusion.
Neuronal function was evaluated with the Tarlov Scoring System.
Spinal cord segments between L2 and L5 were harvested for pathological and biochemical analysis.
Ulinastatin administration significantly improved postischemic neurologic function with concomitant reduction of apoptotic cell death.
In addition, ulinastatin treatment increased SOD activity and decreased MDA content in the spinal cord tissue.
Also, ulinastatin treatment suppressed the protein expressions of Bax and caspase-3 but enhanced Bcl-2 protein expression.
These results suggest that ulinastatin significantly attenuates spinal cord ischemia-reperfusion injury and improves postischemic neuronal function and that this protection might be attributable to its antioxidant and antiapoptotic properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Bingbing& Huang, Weihua& Xiao, Xiaoshan& Xu, Yao& Ma, Songmei& Xia, Zhengyuan. 2015. Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075717
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Bingbing…[et al.]. Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075717
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Bingbing& Huang, Weihua& Xiao, Xiaoshan& Xu, Yao& Ma, Songmei& Xia, Zhengyuan. Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075717
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075717
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر