Potential Therapeutic Role of L-Carnitine in Skeletal Muscle Oxidative Stress and Atrophy Conditions
المؤلفون المشاركون
Luzi, Livio
Benedini, Stefano
Montesano, Anna
Terruzzi, Ileana M.
Senesi, Pamela
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The targeting of nutraceutical treatment to skeletal muscle damage is an emerging area of research, driven by the need for new therapies for a range of muscle-associated diseases.
L-Carnitine (CARN) is an essential nutrient and plays a key role in mitochondrial β-oxidation and in the ubiquitin-proteasome system regulation.
As a dietary supplement to improve athletic performance, CARN has been studied for its potential to enhance β-oxidation.
However, CARN effects on myogenesis, mitochondrial activity, and hypertrophy process are not completely elucidated.
This in vitro study aims to investigate CARN role on skeletal muscle remodeling, differentiation process, and myotubes formation.
We analyzed muscle differentiation and morphological features in C2C12 myoblasts exposed to 5 mM CARN.
Our results showed that CARN was able to accelerate C2C12 myotubes formation and induce morphological changes, characterizing the start of hypertrophy process.
In addition, CARN improved AKT activation and downstream cellular signaling pathways involved in skeletal muscle atrophy process prevention.
Also, CARN positively regulated the pathways involved in oxidative stress defense.
In this work, we provide an interesting novel mechanism of the potential therapeutic use of CARN to treat pathological conditions characterized by skeletal muscle morphological and functional impairment, oxidative stress production, and atrophy process in aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montesano, Anna& Senesi, Pamela& Luzi, Livio& Benedini, Stefano& Terruzzi, Ileana M.. 2015. Potential Therapeutic Role of L-Carnitine in Skeletal Muscle Oxidative Stress and Atrophy Conditions. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montesano, Anna…[et al.]. Potential Therapeutic Role of L-Carnitine in Skeletal Muscle Oxidative Stress and Atrophy Conditions. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montesano, Anna& Senesi, Pamela& Luzi, Livio& Benedini, Stefano& Terruzzi, Ileana M.. Potential Therapeutic Role of L-Carnitine in Skeletal Muscle Oxidative Stress and Atrophy Conditions. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر