Genome-Wide Expression Profiling of AnoxiaReoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis
المؤلفون المشاركون
Cao, Song
Liu, Yun
Sun, Wenting
Zhao, Li
Zhang, Lin
Liu, Xinkui
Yu, Tian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-15
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Mitochondrial ATP-sensitive potassium channel (mitoKATP) is a common end effector of many protective stimuli in myocardial ischemia-reperfusion injury (MIRI).
However, the specific molecular mechanism underlying its myocardial protective effect is not well elucidated.
We characterized an anoxia/reoxygenation (A/R) model using freshly isolated adult rat cardiomyocytes.
MitoKATP status was interfered with its specific opener diazoxide (DZ) or blocker 5-hydroxydecanote (5-HD).
Digital gene expression (DGE) and bioinformatic analysis were deployed.
Three energy metabolism related genes (MT-ND6, Idh2, and Acadl) were upregulated when mitoKATP opened.
In addition, as many as 20 differentially expressed genes (DEGs) were significantly enriched in five energy homeostasis correlated pathways (PPAR, TCA cycle, fatty acid metabolism, and peroxisome).
These findings indicated that mitoKATP opening in MIRI resulted in energy mobilization, which was confirmed by measuring ATP content in cardiomyocytes.
These causal outcomes could be a molecular mechanism of myocardial protection of mitoKATP and suggested that the mitoKATP opening plays a physiologic role in triggering cardiomyocytes’ energy homeostasis during MIRI.
Strategies of modulating energy expenditure during myocardial ischemia-reperfusion may be promising approaches to reduce MIRI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Song& Liu, Yun& Sun, Wenting& Zhao, Li& Zhang, Lin& Liu, Xinkui…[et al.]. 2015. Genome-Wide Expression Profiling of AnoxiaReoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Song…[et al.]. Genome-Wide Expression Profiling of AnoxiaReoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Song& Liu, Yun& Sun, Wenting& Zhao, Li& Zhang, Lin& Liu, Xinkui…[et al.]. Genome-Wide Expression Profiling of AnoxiaReoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر