Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease
المؤلفون المشاركون
Masci, Alessandra
Mattioli, Roberto
Costantino, Paolo
Baima, Simona
Morelli, Giorgio
Punzi, Pasqualina
Giordano, Cesare
d’Erme, Maria
Mosca, Luciana
Donini, Lorenzo Maria
Pinto, Alessandro
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
β-Amyloid peptide (Aβ) aberrant production and aggregation are major factors implicated in the pathogenesis of Alzheimer’s disease (AD), causing neuronal death via oxidative stress.
Several studies have highlighted the importance of polyphenolic antioxidant compounds in the treatment of AD, but complex food matrices, characterized by a different relative content of these phytochemicals, have been neglected.
In the present study, we analyzed the protective effect on SH-SY5Y cells treated with the fragment Aβ25–35 by two crude juices of broccoli sprouts containing different amounts of phenolic compounds as a result of different growth conditions.
Both juices protected against Aβ-induced cytotoxicity and apoptotic cell death as evidenced by cell viability, nuclear chromatin condensation, and apoptotic body formation measurements.
These effects were mediated by the modulation of the mitochondrial function and of the HSP70 gene transcription and expression.
Furthermore, the juices upregulated the intracellular glutathione content and mRNA levels or activity of antioxidant enzymes such as heme oxygenase-1, thioredoxin, thioredoxin reductase, and NAD(P)H:quinone oxidoreductase 1 via activation of NF-E2-related factor 2 (Nrf2).
Although the effects of the two juices were similar, the juice enriched in phenolic compounds showed a greater efficacy in inducing the activation of the Nrf2 signalling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masci, Alessandra& Mattioli, Roberto& Costantino, Paolo& Baima, Simona& Morelli, Giorgio& Punzi, Pasqualina…[et al.]. 2015. Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masci, Alessandra…[et al.]. Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masci, Alessandra& Mattioli, Roberto& Costantino, Paolo& Baima, Simona& Morelli, Giorgio& Punzi, Pasqualina…[et al.]. Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر