Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation

المؤلفون المشاركون

Shigetomi, Hiroshi
Kobayashi, Hiroshi
Yoshimoto, Chiharu
Iwabuchi, Takuya

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-06-21

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

The aim of this study was to investigate the role of redox status in endometriosis and its malignant transformation.

A search was conducted between 1990 and 2014 through the English language literature (online MEDLINE PubMed database) using the keywords endometriosis combined with malignant transformation, oxidative stress, and antioxidant defense.

In benign endometriosis, autoxidation and Fenton reaction of hemoglobin from the ferrous Fe2+ (oxyhemoglobin) state to the ferric Fe3+ (methemoglobin) state lead to production of excess reactive oxygen species (ROS) such as O 2 - and O H ∙ .

Hemoglobin, heme, and iron derivatives in endometriotic cysts cause distortion in the homeostatic redox balance.

Excess oxidative stress could trigger DNA damage and cell death.

In contrast, endometriosis-associated ovarian cancer (EAOC) might be associated with an effective antioxidant defense, including heme oxygenases, cytochrome P450 family, and glutathione transferase family.

The pattern of redox balance supports that enhanced antioxidants may be involved in the pathogenesis of malignant transformation.

In conclusion, oxidant/antioxidant balance function is a double-edged sword, promoting cell death or carcinogenesis.

Upregulation of antioxidant functions in endometriotic cyst may result in restoration of cell survival and subsequent malignant transformation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Iwabuchi, Takuya& Yoshimoto, Chiharu& Shigetomi, Hiroshi& Kobayashi, Hiroshi. 2015. Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075796

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Iwabuchi, Takuya…[et al.]. Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075796

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Iwabuchi, Takuya& Yoshimoto, Chiharu& Shigetomi, Hiroshi& Kobayashi, Hiroshi. Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075796

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1075796