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Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through AktmTOR Signaling
المؤلفون المشاركون
Zhang, Dayong
Yan, Bingxi
Yu, Shanshan
Zhang, Chong
Wang, Baoming
Wang, Yayan
Wang, Junbo
Yuan, Zhanggen
Zhang, Lihuang
Pan, Jianping
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Increasing evidences indicate that reactive oxygen species are the main factor promoting stem cell aging.
Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in organ and cellular aging.
However, the potential for CoQ10 to protect stem cell aging has not been fully evaluated, and the mechanisms of cell senescence inhibited by CoQ10 are still poorly understood.
Our previous study had indicated that D-galactose (D-gal) can remarkably induce mesenchymal stem cell (MSC) aging through promoting intracellular ROS generation.
In this study, we showed that CoQ10 could significantly inhibit MSC aging induced by D-gal.
Moreover, in the CoQ10 group, the expression of p-Akt and p-mTOR was clearly reduced compared with that in the D-gal group.
However, after Akt activating by CA-Akt plasmid, the senescence-cell number in the CoQ10 group was significantly higher than that in the control group.
These results indicated that CoQ10 could inhibit D-gal-induced MSC aging through the Akt/mTOR signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Dayong& Yan, Bingxi& Yu, Shanshan& Zhang, Chong& Wang, Baoming& Wang, Yayan…[et al.]. 2015. Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through AktmTOR Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Dayong…[et al.]. Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through AktmTOR Signaling. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Dayong& Yan, Bingxi& Yu, Shanshan& Zhang, Chong& Wang, Baoming& Wang, Yayan…[et al.]. Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through AktmTOR Signaling. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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